Effect of tumor necrosis factor-alpha on differentiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat / 生理学报
Acta Physiologica Sinica
;
(6): 183-186, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-318920
ABSTRACT
To observe the influence of tumor necrosis factor-alpha (TNF-alpha) on differentiation of rat mesencephalic neural stem cells (NSCs), the numbers of neurons, astrocytes and oligodendrocytes generated from NSCs were analyzed after differentiation for 3 days by using immunocytochemistry technique. The results show that (1) TNF-alpha enhanced the proportions of neurons and oligodendrocytes in progeny of NSCs; and (2) TNF-alpha induced the proliferation of oligodendrocytes derived from NSCs, but the proliferation of astrocytes was not influenced by TNF-alpha. We conclude that the TNF-alpha could influence the application of NSCs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Mesencéfalo
/
Diferenciação Celular
/
Oligodendroglia
/
Astrócitos
/
Fator de Necrose Tumoral alfa
/
Ratos Sprague-Dawley
/
Biologia Celular
/
Proliferação de Células
/
Células-Tronco Neurais
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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