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Kappa-opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats / 生理学报
Acta Physiologica Sinica ; (6): 91-95, 2003.
Artigo em Inglês | WPRIM | ID: wpr-318936
ABSTRACT
To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) on aorta in the rat, isolated aortic ring was perfused and the tension of the vessel was measured. It was shown (1) kappa-opioid receptor stimulation with U50,488H relaxed rat aorta dose-dependently; (2) the relaxation effect of U50,488H on aorta was partially endothelium-dependent; (3) the relaxation effect of U50,488H was significantly attenuated in the presence of glybenclamide and glipizide, two ATP-sensitive K(+) channel (K(ATP)) blockers; and (4) the relaxation effect of U50,488H on vessel bore no relationship to muscarinic-receptor, beta-adrenoceptor, prostaglandin and nitric oxide (NO). These results indicate that kappa-opioid receptor stimulation with U50,488H relaxes the aortic artery at least partially via K(ATP) channel in the rat.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aorta / Farmacologia / Fisiologia / Vasodilatação / Técnicas In Vitro / Ratos Sprague-Dawley / Receptores Opioides kappa / (trans)-Isômero de 3,4-dicloro-N-metil-N-(2-(1-pirrolidinil)-ciclo-hexil)-benzenoacetamida / Canais KATP / Metabolismo Limite: Animais Idioma: Inglês Revista: Acta Physiologica Sinica Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aorta / Farmacologia / Fisiologia / Vasodilatação / Técnicas In Vitro / Ratos Sprague-Dawley / Receptores Opioides kappa / (trans)-Isômero de 3,4-dicloro-N-metil-N-(2-(1-pirrolidinil)-ciclo-hexil)-benzenoacetamida / Canais KATP / Metabolismo Limite: Animais Idioma: Inglês Revista: Acta Physiologica Sinica Ano de publicação: 2003 Tipo de documento: Artigo