Effect of angiotensin II on L-type calcium channel in ischemic ventricular myocytes of the guinea pig / 生理学报
Acta Physiologica Sinica
;
(6): 375-378, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-318982
ABSTRACT
Using whole cell patch clamp, the effects of angiotensin II (Ang II) on the current L-type calcium channel (I(Ca.L)) were observed in guinea pig isolated ventricular myocytes under simulated ischemia condition, which was realized through hypoxia, glucose deficiency, high lactic acid and acidosis. The results showed that, under the condition of simulated ischemia, the peak of I(Ca.L) was reduced with maximal activation potential at 0 mV. Administration of Ang II (100 nmol/L) enhanced the peak of I(Ca.L) during ischemia and shifted the maximal activation potential to -10 mV. The possible mechanism of these effects is discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Angiotensina II
/
Células Cultivadas
/
Técnicas de Patch-Clamp
/
Canais de Cálcio Tipo L
/
Biologia Celular
/
Miócitos Cardíacos
/
Cobaias
/
Ventrículos do Coração
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2002
Tipo de documento:
Artigo
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