Expression of proliferating cell nuclear antigen/bcl-2 in gray gingival tissue / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the expression of PCNA/bcl-2 protein in gray and normal gingival tissue, and to investigate the biological effect of procelain-fused-to-metals (PFM).</p><p><b>METHODS</b>Gray gingival tissue animal model was established by PFM prosthesis and immunohistochemistry S-P method was used to detect the PCNA/bcl-2 protein expression in gingival tissue after 3 months, 6 months in PFM groups and control group.</p><p><b>RESULTS</b>The expression of PCNA had significant difference between the 3th month group and the control group (P < 0.05); no significant difference was found between the 6th month group and the control group (P > 0.05). The expression of bcl-2 had no significant difference between the 6th month group and the control group (P > 0.05).</p><p><b>CONCLUSION</b>There were a correlation between the expression of PCNA and inflammation of the gray gingival tissue; The expression of PCNA and bcl-2 protein does not indicate that gray gingival tissue had dysplasia change.</p>