The study on the regeneration of skeletal muscles after denervation / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 89-92, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-319051
ABSTRACT
<p><b>OBJECTIVE</b>To study the degeneration and regeneration of skeletal muscle after denervation.</p><p><b>METHODS</b>Denervation was carried out in gastrocnemius muscles in 30 adult BALB/C mice by cutting the sciatic nerve. The gastrocnemius muscles were removed at 1, 2, 4, 8, 12, 16 weeks after denervation, respectively. Specimens were processed for histological study and immunohistochemical technique.</p><p><b>RESULTS</b>Muscle fiber atrophy followed by degerneration and regeneration was observed in the early period of denervation. Fusion of the regenerated muscle cells with each other followed by degeneration of the cells and growth of fibro-connective tissue were observed in the later stage. The expression of myoglobin and actin decreased in 1-4 weeks after denervation. The postive expression of the proteins was observed in some 8 weeks' cells and in many degenerated 12-14 weeks' muscle cells.</p><p><b>CONCLUSION</b>Degeneration and regeneration may coexisted in the denervated muscles. The regenerated muscle cells can't fully develop due to the deficit of nerve regulation and degenerate again. The regenerated muscle cells will melt each other and can't develop to mature muscle fiber in the later stage.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Nervo Isquiático
/
Cirurgia Geral
/
Atrofia Muscular
/
Músculo Esquelético
/
Fibras Musculares Esqueléticas
/
Camundongos Endogâmicos BALB C
/
Denervação Muscular
/
Regeneração Nervosa
Limite:
Animais
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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