Study on endotoxin levels of acute and chronic periapical periodontitis / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare the endotoxin levels between acute and chronic periapical periodontitis with different clinical symptoms.</p><p><b>METHODS</b>10 cases of acute periapical priodontitis(Group 1), 10 cases of chronic periapical periodontitis (group 2, the diameter of apical radiolucency area was less than 2 mm), 10 cases of chronic periapical periodontitis with sinus(group 3, the diameter of apical radiolucency area was greater than 2 mm), 10 cases of chronic periapical periodontitis without sinus (group 4, the diameter of apical radiolucency area was greater than 2 mm), were included in the study. Chromogenic substrate method of limulus amebocyte lysate(LAL) test was used to measure the endotoxin level.</p><p><b>RESULTS</b>Endotoxin concentrations in group 2 were significantly lower than those in group 1, group 3 and group 4(P < 0.01).</p><p><b>CONCLUSION</b>Endotoxin plays a very important role in the initiation and development of periapical periodotitis and is closely associated with clinical symptoms and apical radiolucency degree.</p>