Expression of nucleostemin in prostate cancer tissues and its clinical significance / 中华男科学杂志
National Journal of Andrology
;
(12): 418-422, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-319221
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of the nucleostemin (NS) gene in prostate cancer (PCa) tissues and its clinical significance.</p><p><b>METHODS</b>We detected the NS expression in PCa, benign prostatic hyperplasia (BPH) and high grade prostatic intraepithelial neoplasia (HGPIN) tissues by RT-PCR and immunohistochemistry, and analyzed the correlation between the expression of the NS protein and the clinical variables of PCa.</p><p><b>RESULTS</b>The NS mRNA level was markedly higher in the PCa than in the BPH tissues. The rates of strongly positive, positive and weakly positive expressions of the NS protein were 48.8%, 36.6% and 12.2% in PCa, 4.0%, 32.0% and 56.0% in BPH, and 5.0%, 25.0% and 60.0% in HGPIN, respectively. The expression level of the NS protein was significantly higher in PCa than in BPH and HGPIN (P < 0.05). The expression of the NS gene was negatively correlated with the degree of cell differentiation in the PCa tissues, the worse the differentiation, the higher the NS expression level.</p><p><b>CONCLUSION</b>The NS gene is highly expressed in PCa tissues and may have an important role in the adverse differentiation and malignant proliferation of prostate cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias da Próstata
/
RNA Mensageiro
/
Imuno-Histoquímica
/
Proteínas Nucleares
/
Proteínas de Transporte
/
Proteínas de Ligação ao GTP
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Genética
/
Metabolismo
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2008
Tipo de documento:
Artigo
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