The roles of carbon monoxide on hypoxic pulmonary vasoconstriction / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 261-263, 2002.
Article
em Zh
| WPRIM
| ID: wpr-319313
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM AND METHODS</b>To study the roles of carbon monoxide on hypoxic pulmonary vasoconstriction (HPV) by investigating the effects of exogenous carbon monoxide and heme oxygenase inhibitor ZnPPIX on hypoxic vasoconstriction reaction of isolated rat pulmonary arterial rings (PAR).</p><p><b>RESULTS</b>Hypoxia caused constriction in PAR preconstricted by PE. Both ZnPPIX and carbon monoxide inhibited hypoxic pulmonary constriction significantly by increasing the cGMP level after hypoxia.</p><p><b>CONCLUSION</b>ZnPPIX and exogenous carbon monoxide can inhibit HPV. The reduction of cGMP induced by the decreased of CO may be one of reasons of HPV.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
/
Artéria Pulmonar
/
Vasoconstrição
/
Técnicas In Vitro
/
Monóxido de Carbono
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Ratos Wistar
/
Hipóxia
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2002
Tipo de documento:
Article