Comparison of pharmacological characteristics of the endothelial target for acetylcholine between big artery and small artery / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 252-256, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-319315
ABSTRACT
<p><b>AIM</b>To compare the differences of pharmacological characteristics of the endothelial target for acetylcholine (ETA) between rat aorta and tail artery.</p><p><b>METHODS</b>Differences in the endothelium-dependent relaxation induced by acetylcholine (ACh 10(-8) - 10(-4) mol/L) were studied using isolated rat tail artery helical strips and aortic rings, so that the pharmacological characteristics of ETA in small artery can be observed.</p><p><b>RESULTS</b>ACh-induced endothelium-dependent relaxation was observed both in rat tail artery strips and in aortic rings precontracted with potassium chloride (60 mmol/L) in a concentration-dependent manner. In tail artery this effect was partially blocked by L-N(omega)-Nitro-arginine methyl ester (L-NAME 10(-4) mol/L) or methylene blue (MB 10(-5) mol/L), together with indomethacin (Indo 10(-4) mol/L), but in aorta it was completely blocked by L-NAME or MB.</p><p><b>CONCLUSION</b>It is different of the pharmacological characteristics of ETA between big artery and small artery. A non-NO and non-PGI2 relaxing factor, together with nitric oxide (NO) and prostacyclin (PGI2), mediates endothelium-dependent vasorelaxation induced by ACh in small artery, but NO may be the principal endothelial vasodilator substance in big artery.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aorta
/
Farmacologia
/
Fisiologia
/
Artérias
/
Vasodilatação
/
Técnicas In Vitro
/
Endotélio Vascular
/
Acetilcolina
/
Ratos Wistar
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2002
Tipo de documento:
Artigo
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