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TGF-beta and HSP70 expression in human skin fibroblasts after ultraviolet B irradiation / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 166-168, 2002.
Artigo em Chinês | WPRIM | ID: wpr-319347
ABSTRACT
<p><b>AIM AND METHODS</b>For further understanding the signal transduction pathway of the inducible HSP70 expression the expression of TGF-betamRNA and HSP70 in fibroblasts after 5, 10 and 20 mJ/cm2 of UVB irradiation, and the content of TGF-beta protein in culture supernatants and HSP70 expression in fibroblasts by 10mJ/cm2 UVB irradiation after preincubation with the anti-human TGF-beta receptor II antibody were observed.</p><p><b>RESULTS</b>(1) TGF-betamRNA expression positively correlated with HSP70 expression in UVB irradiation of different doses (r = 0. 906). (2) TGF-beta content in the culture supernatants negatively correlated with the HSP70 expression induced in adding anti-human TGF-beta receptor II antibody and UVB treatment condition (r = - 0.995).</p><p><b>CONCLUSION</b>TheTGF-beta play an important action in HSP70 inducing by UVB irradiation.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Efeitos da Radiação / Pele / Raios Ultravioleta / Células Cultivadas / Fator de Crescimento Transformador beta / Proteínas de Choque Térmico HSP70 / Biologia Celular / Fibroblastos / Metabolismo Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Efeitos da Radiação / Pele / Raios Ultravioleta / Células Cultivadas / Fator de Crescimento Transformador beta / Proteínas de Choque Térmico HSP70 / Biologia Celular / Fibroblastos / Metabolismo Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Applied Physiology Ano de publicação: 2002 Tipo de documento: Artigo