Effect of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 155-158, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-319350
ABSTRACT
<p><b>AIM AND METHODS</b>To observe the effects of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig.</p><p><b>METHODS</b>Using inside-out configuration of patch-clamp single channel recording technique.</p><p><b>RESULTS</b>Puerarin 20 micromol/L, 40 micromol/L, 80 microml/L could inhibit the open-close rate of K+ channel of isolated ventricular myocyte in guinea pig. At 80 micromol/L, Po was decreased from 0.867 +/- 0.13 to 0.019 +/- 0.01 (n = 5, P < 0.05).</p><p><b>CONCLUSION</b>Puerarin can inhibit K+ channel of isolated ventricular myocyte in guinea pig. It may be the mechanism of Puerarin against arrhythmias in molecular level.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Canais de Potássio
/
Técnicas de Patch-Clamp
/
Biologia Celular
/
Miócitos Cardíacos
/
Cobaias
/
Ventrículos do Coração
/
Isoflavonas
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2002
Tipo de documento:
Artigo
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