Current alteration of K(V) channel in SLE patient's peripheral blood lymphocytes and it's significant / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 68-70, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-319377
ABSTRACT
<p><b>AIM</b>To observe the property alteration of K(v) channel in SLE patient's peripheral blood lymphocyte and its significant.</p><p><b>METHODS</b>The patch-clamp technique was used to record the current of K(V) channel in SLE patient's peripheral lymphocyte.</p><p><b>RESULTS</b>The current amplitude of K(V) channel in the SLE patient's lymphocytes decreased, it was (258.6 +/- 112.5) pA in healthy people, but in SLE patient it was (139.4 +/- 58.5) pA (P < 0.05). There was no other changes in the property of channel, include activation potential, inactivation property, channel closing kinetics and its pharmacological property.</p><p><b>CONCLUSION</b>The decline of SLE patient's cell immunity may be related to the decrease of the amplitude of K(V) channel current.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Sangue
/
Linfócitos
/
Monócitos
/
Estudos de Casos e Controles
/
Membrana Celular
/
Técnicas de Patch-Clamp
/
Contagem de Linfócitos
/
Canais de Potássio de Abertura Dependente da Tensão da Membrana
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2002
Tipo de documento:
Artigo
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