Correlation of autophagy-associated gene Atg5 with tumorigenesis of prostate cancer / 中华男科学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the correlation of the autophagy-associated gene Atg5 with the pathogenesis of prostate cancer.</p><p><b>METHODS</b>Using real-time fluorescent quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry, we detected the expression of Atg5 in 50 cases of prostate intraepithelial neoplasm (PIN), 69 cases of prostate cancer (PCa), and 30 cases of benign prostatic hyperplasia (BPH).</p><p><b>RESULTS</b>The expression level of Atg5 mRNA was significantly higher in PIN (5.270 ± 0.230) and PCa (5.131 ± 0.252) than in the BPH tissue (1.723 ± 0.017) (P <0.01), and so was the positive rate of the Atg5 expression in the patients of the PIN group (94%) and PCa group (88.4%) than in those of the BPH group (6.7%) (P<0.01), but with no statistically significant differences between the PIN and PCa groups (P >0.05). No significant correlation was observed between the expression of Atg5 and the Gleason score of PCa (P >0.05).</p><p><b>CONCLUSION</b>The upregulated expression of Atg5 might play a role in the tumorigenesis of prostate cancer.</p>