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Study on application of bioassay method in drug-release evaluation in vitro of Salvia miltiorrhiza hydrophilic gel matrix tablets / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 3880-3887, 2013.
Artigo em Chinês | WPRIM | ID: wpr-319685
ABSTRACT
To investigate the feasible application of the bioassay method in the evaluation of traditional Chinese medicine sustained-release preparations, develop a rapid drug-release evaluation method in vitro for multi-component preparations, and replace the biological activity determination method characterizing the overall behavior with the existing drug-release evaluation method for single component, in order to give better instruction for sustained-release preparations. HPLC was adopted to determine dissolution media, drug releasing rates, and accumulative releasing of active ingredients (salvianolic acid B, protocatechuic aldehyde and rosmarinic acid) of Salvia Miltiorrhiza hydrophilic gel matrix tablets. The ultraviolet spectroscopy was adopted to determine the antioxidant activity of release media, and evaluate the correlation between the drug-time curve of various drug components and the drug-time curve of the total antioxidant activity. The correlation coefficient between the drug-release curve of various components and the drug-time curve of the total antioxidant activity was higher than the critical value r 0.898 (P < 0.001). This indicated that the drug-release curve of the three phenolic acids and the drug-time curve of the total antioxidant activity had a good correlation in different conditions, such as dissolution media, release rates and component ratios. The bioassay method for determination was feasible, simple and convenient for preparation quality evaluation and prescription design in the place of in vitro dissolution.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solubilidade / Comprimidos / Bioensaio / Medicamentos de Ervas Chinesas / Cinética / Química / Salvia miltiorrhiza / Preparações de Ação Retardada / Métodos / Antioxidantes Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Solubilidade / Comprimidos / Bioensaio / Medicamentos de Ervas Chinesas / Cinética / Química / Salvia miltiorrhiza / Preparações de Ação Retardada / Métodos / Antioxidantes Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2013 Tipo de documento: Artigo