Hemodynamics and aortic tension induced by two septic shock models in rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 572-576, 2010.
Article
em Zh
| WPRIM
| ID: wpr-319856
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the ventricular-dynamic parameters and thoracic aorta tension induced by two septic shock models in rats.</p><p><b>METHODS</b>Septic shock models were induced by cecal ligation or puncture (CLP) and intraperitoneal injection of lipopolysaccharide (LPS) in rats. The carotid artery was cannulated and connected to a pressure transducer to determine mean arterial blood pressure (MABP). Ventricular dynamic parameters, including heart rate (HR), left ventricular developed pressure (LVDP) and maximal rise/fall velocity of ventricular pressure (± dP/dtmax) were determined. Isolated thoracic rings were mounted on an organ bath and the tension of the vessel was recorded.</p><p><b>RESULT</b>The mortality was 65.2% in CLP shock rats, but no death in LPS shock rats. The MABP and HR of CLP rats were decreased more prominently than those of LPS rats (P < 0.01). Contraction induced by high K(+) (60 mmol/L) or 10⁻⁶ mol/L phenylephrine (PE) in endothelium-intact and endothelium-denuded aortic rings was all attenuated, but in LPS rats it was more prominent (P < 0.01).</p><p><b>CONCLUSION</b>Two rat septic shock models can decrease ventricular-dynamic parameters and vasoconstriction responsiveness of aorta. The ventricular-dynamic parameters decrease more prominently in CLP model, while vasoconstriction responsiveness of aorta changes more in LPS model.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
/
Choque Séptico
/
Cirurgia Geral
/
Vasoconstrição
/
Distribuição Aleatória
/
Ceco
/
Lipopolissacarídeos
/
Ratos Sprague-Dawley
/
Pressão Ventricular
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2010
Tipo de documento:
Article