Early high-volume hemofiltration treatment in severe sepsis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 483-486, 2010.
Article
em Zh
| WPRIM
| ID: wpr-319872
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of early application of high-volume hemofiltration treatment (HVHF) on the levels of lactic acid, pro-inflammatory cytokines and C-reactive protein (CRP) in plasma, as well as APACHE II score in patients suffering from severe sepsis.</p><p><b>METHODS</b>Thirty patients meeting the diagnosis of severe sepsis were enrolled in the trial within 24 hours of insults. The level of lactic acid, interleukin-6 (IL-6) and CRP in plasma were measured before HVHF and at 24, 48 or 72 h following HVHF treatment.</p><p><b>RESULT</b>The plasma levels of lactic acid and IL-6 decreased significantly at 24 h, 48 h, 72 h after HVHF (P <0.05), while, IL-10 did not differ significantly following HVHF (P>0.05), when compared with that before HVHF.</p><p><b>CONCLUSION</b>The early application of HVHF could clear the plasma lactic acid and pro-inflammatory cytokines, and improve the tissue oxygenation in severe sepsis.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Terapêutica
/
Sangue
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Proteína C-Reativa
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Hemofiltração
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Interleucina-6
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Resultado do Tratamento
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Interleucina-10
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Sepse
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APACHE
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Ácido Láctico
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2010
Tipo de documento:
Article