Design, synthesis and antiproliferative activity in cancer cells of novel 18β-glycyrrhetinic acid derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1263-1271, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-320091
ABSTRACT
To investigate the anticancer effects of ring C in 18β-glycyrrhetinic acid (GA), a series of GA derivatives featured with 9(11)-ene moiety in ring C were designed and synthesized. The structures were confirmed by IR, LC-MS and 1H NMR. Their inhibitory effects towards human prostate cancer PC-3 and leukemia HL-60 cell lines were determined. Most of the derivatives displayed stronger antiproliferative activities than GA. Particularly, compound 14 showed promising anticancer activity with the GI50 values of 4.48 µmol · L(-1) and 1.2 µmol · L(-1) against PC-3 and HL-60 cells respectively, which is worth further study.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Neoplasias da Próstata
/
Desenho de Fármacos
/
Química
/
Células HL-60
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Ácido Glicirretínico
/
Antineoplásicos
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Artigo
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