Advances in the study of site-specific antibody-drug conjugates / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1225-1231, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-320097
ABSTRACT
Antibody drug conjugates (ADCs) are an emerging class of targeted therapeutics with the potential to improve therapeutic index over the traditional chemotherapy. However, it is difficult to control the site and stoichiometry of conjugation in mAb, typically resulting in heterogeneous mixtures of ADCs that are difficult to optimize. New methods for site-specific drug attachment allow development of more homogeneous conjugates and control of the site of drug attachment. In this article, the new literature on development of ADCs and site-specific ADCs is reviewed. In addition, we summarized the various strategies in production of site-specific ADCs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sítios de Ligação de Anticorpos
/
Química
/
Imunoconjugados
/
Anticorpos Monoclonais
/
Especificidade de Anticorpos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Artigo
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