Association between CTLA-4 gene polymorphism and susceptibility to cervical cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 681-684, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-320107
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between CTLA-4 +49A/G polymorphisms and the risk of susceptibility to cervical cancer.</p><p><b>METHODS</b>A hospital-based case-control study was conducted. 314 cases with primary cervical cancer and 320 healthy controls were collected and genotyped by PCR-based RFLP for +49A/G polymorphisms in the CTLA-4 gene.</p><p><b>RESULTS</b>The A allele and AA genotype of CTLA-4 gene were 32.5% and 9.6% in the patients, and 25.8% and 5.6% in the controls, respectively. Subjects with CTLA-4 +49AA genotype conferred a higher risk of cervical cancer (OR = 2.06, 95%CI 1.10 - 3.85; P = 0.024). However, the correlation between AA genotype in CTLA-4 polymorphisms and clinicopathological characteristics was not significant.</p><p><b>CONCLUSION</b>The results of this study suggest that CTLA4 gene is associated with cervical cancer risk and may be a susceptible gene of cervical cancer.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Polimorfismo Genético
/
Cirurgia Geral
/
Polimorfismo de Fragmento de Restrição
/
Carcinoma in Situ
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Estudos de Casos e Controles
/
Neoplasias do Colo do Útero
/
Fatores de Risco
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2011
Tipo de documento:
Artigo
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