Relationship between pathological development of phlegm-stasis and expression of actin in vascular smooth muscle cell in atherosclerosis rat model / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the dynamic change of Phlegm-stasis in the rat atherosclerotic model as the time goes on.</p><p><b>METHODS</b>Adopting high fat forage fed to develop the atherosclerotic model in rats, and the changes of blood lipid, hemorrheology, blood glucose, insulin and vascular smooth muscle cell (VSMC) actin expression were detected by biochemical and immunohistochemical assay at various time points after modeling.</p><p><b>RESULTS</b>The expression of VSMC actin gradually increased along with the change of model rats' Syndrome from Phlegm to stasis, i.e., the change of parameters, including blood lipid, hemorrheologic parameters, blood glucose, insulin and insulin sensitive indexes along with the aggravation of disease.</p><p><b>CONCLUSION</b>The expression of VSMC actin could be the molecular mechanism for the Syndrome developing from Phlegm to stasis in atherosclerotic rats.</p>