Compared Markov with fractal models by using single-channel experimental and simulation data / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 923-928, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-320451
ABSTRACT
The gating mechanical kinetical of ion channels has been modeled as a Markov process. In these models it is assumed that the channel protein has a small number of discrete conformational states and kinetic rate constants connecting these states are constant, the transition rate constants among the states is independent both of time and of the previous channel activity. It is assumed in Liebovitch's fractal model that the channel exists in an infinite number of energy states, consequently, transitions from one conductance state to another would be governed by a continuum of rate constants. In this paper, a statistical comparison is presented of Markov and fractal models of ion channel gating, the analysis is based on single-channel data from ion channel voltage-dependence K+ single channel of neuron cell and simulation data from three-states Markov model.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Simulação por Computador
/
Canais de Potássio
/
Ativação do Canal Iônico
/
Células Cultivadas
/
Cadeias de Markov
/
Ratos Sprague-Dawley
/
Fractais
/
Técnicas de Patch-Clamp
/
Eletrofisiologia
Tipo de estudo:
Avaliação Econômica em Saúde
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2006
Tipo de documento:
Artigo
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