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A case of treatment of cervical adenocarcinoma associated with pregnancy by zinc-citrate compound (SeLava(R)) / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology ; : 2612-2619, 2006.
Artigo em Coreano | WPRIM | ID: wpr-32049
ABSTRACT
Cervical carcinoma is the second leading cause of death from cancer in women worldwide. It is well known that human papillomaviruses (HPVs) is the etiologic agent of cervical neoplasia and cervical cancer. Zinc has been shown to inhibit the growth of malignant cell lines by inducing apoptosis and cell cycle arrest. Recently it was reported that zinc-citrate compound (CIZAR(R)) has a cytotoxic effect on choriocarcinoma cell line and ovarian adenocarcinoma cell line and suppresses its proliferation inducing apoptosis. CIZAR(R) prevents the proliferation by inactivation of m-aconitase activity and induces apoptosis by increasing Bax expression and reducing Bcl-2 expression and inactivation of telomerase. We report one patient of cervical adenocarcinoma with HPV infection, who desires to continue pregnancy, treated by daily topical application of SeLava(R) which contains zinc-citrate compound (CIZAR(R)). We followed up the cytologic, pathologic and coloposcopic changes of healing process.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Zinco / Adenocarcinoma / Coriocarcinoma / Linhagem Celular / Neoplasias do Colo do Útero / Causas de Morte / Apoptose / Telomerase / Pontos de Checagem do Ciclo Celular Limite: Feminino / Humanos / Gravidez Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Zinco / Adenocarcinoma / Coriocarcinoma / Linhagem Celular / Neoplasias do Colo do Útero / Causas de Morte / Apoptose / Telomerase / Pontos de Checagem do Ciclo Celular Limite: Feminino / Humanos / Gravidez Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 2006 Tipo de documento: Artigo