Radiation and concomitant chemotherapy for patients with glioblastoma multiforme / 癌症
Chinese Journal of Cancer
;
(12): 25-31, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-320542
ABSTRACT
Postoperative external beam radiotherapy was considered the standard adjuvant treatment for patients with glioblastoma multiforme until the advent of using the drug temozolomide (TMZ) in addition to radiotherapy. High-dose volume should be focal, minimizing whole brain irradiation. Modern imaging, using several magnetic resonance sequences, has improved the planning target volume definition. The total dose delivered should be in the range of 60 Gy in fraction sizes of 1.8-2.0 Gy. Currently, TMZ concomitant and adjuvant to radiotherapy has become the standard of care for glioblastoma multiforme patients. Radiotherapy dose-intensification and radiosensitizer approaches have not improved the outcome. In spite of the lack of high quality evidence, stereotactic radiotherapy can be considered for a selected group of patients. For elderly patients, data suggest that the same survival benefit can be achieved with similar morbidity using a shorter course of radiotherapy (hypofractionation). Elderly patients with tumors that exhibit methylation of the O-6-methylguanine-DNA methyltransferase promoter can benefit from TMZ alone.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Neoplasias Encefálicas
/
Metilases de Modificação do DNA
/
Radiocirurgia
/
Glioblastoma
/
Antineoplásicos Alquilantes
/
Metilação de DNA
/
Fracionamento da Dose de Radiação
/
Proteínas Supressoras de Tumor
/
Dacarbazina
Limite:
Idoso
/
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2014
Tipo de documento:
Artigo
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