The role of EPH receptors in cancer-related epithelial-mesenchymal transition / 癌症
Chinese Journal of Cancer
;
(12): 231-240, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-320551
ABSTRACT
Erythropoietin-producing hepatoma (EPH) receptors are considered the largest family of receptor tyrosine kinases and play key roles in physiological and pathologic processes in development and disease. EPH receptors are often overexpressed in human malignancies and are associated with poor prognosis. However, the functions of EPH receptors in epithelial-mesenchymal transition (EMT) remain largely unknown. This review depicts the relationship between EPH receptors and the EMT marker E-cadherin as well as the crosstalk between EPH receptors and the signaling pathways involved EMT. Further discussion is focused on the clinical significance of EPH receptors as candidates for targeting in cancer therapeutics. Finally, we summarize how targeted inhibition of both EPH receptors and EMT-related signaling pathways represents a novel strategy for cancer treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Transdução de Sinais
/
Caderinas
/
Receptores Proteína Tirosina Quinases
/
Receptores da Família Eph
/
Transição Epitelial-Mesenquimal
/
Neoplasias
/
Antineoplásicos
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2014
Tipo de documento:
Artigo
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