Targeted therapy: tailoring cancer treatment / 癌症
Chinese Journal of Cancer
;
(12): 363-364, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-320568
ABSTRACT
Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected signaling pathways and molecular targets involved in human cancers including Aurora kinases, PI3K/mTOR signaling, FOXO-FOXM1 axis, and MDM2/MDM4-p53 interaction. Understanding the molecular mechanisms for tumorigenesis and development of drug resistance will provide new insights into drug discovery and design of therapeutic strategies for targeted therapies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Proteínas Nucleares
/
Transdução de Sinais
/
Proteína Supressora de Tumor p53
/
Proteínas Proto-Oncogênicas
/
Resistencia a Medicamentos Antineoplásicos
/
Fosfatidilinositol 3-Quinases
/
Proteínas Proto-Oncogênicas c-mdm2
/
Fatores de Transcrição Forkhead
/
Serina-Treonina Quinases TOR
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2013
Tipo de documento:
Artigo
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