Lymphoma and cerebral vasculitis in association with X-linked lymphoproliferative disease / 癌症
Chinese Journal of Cancer
;
(12): 673-677, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-320576
ABSTRACT
Lymphoma is seen in up to 30% of patients with X-linked lymphoproliferative disease (XLP), but cerebral vasculitis related with XLP after cure of Burkitt lymphoma is rarely reported. We describe a case of a 5-year-old boy with XLP who developed cerebral vasculitis two years after cure of Burkitt lymphoma. He had Burkitt lymphoma at the age of 3 years and received chemotherapy (non-Hodgkin's lymphoma-Berlin-Frankfurt-Milan-90 protocol plus rituximab), which induced complete remission over the following two years. At the age of 5 years, the patient first developed headache, vomiting, and then intellectual and motorial retrogression. His condition was not improved after anti-infection, dehydration, or dexamethasone therapy. No tumor cells were found in his cerebrospinal fluid. Magnetic resonance imaging showed multiple non-homogeneous, hypodense masses along the bilateral cortex. Pathology after biopsy revealed hyperplasia of neurogliocytes and vessels, accompanied by lymphocyte infiltration but no tumor cell infiltration. Despite aggressive treatment, his cognition and motor functions deteriorated in response to progressive cerebral changes. The patient is presently in a vegetative state. We present this case to inform clinicians of association between lymphoma and immunodeficiency and explore an optimal treatment for lymphoma patients with compromised immune system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imageamento por Ressonância Magnética
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Linfoma de Burkitt
/
Resultado do Tratamento
/
Vasculite do Sistema Nervoso Central
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Anticorpos Monoclonais Murinos
/
Rituximab
/
Transtornos Linfoproliferativos
Tipo de estudo:
Guia de Prática Clínica
Limite:
Criança, pré-escolar
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Journal of Cancer
Ano de publicação:
2013
Tipo de documento:
Artigo
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