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Germinal-center type B-cell classification and clinical characteristics of Chinese pediatric diffuse large B-cell lymphoma: a report of 76 cases / 癌症
Chinese Journal of Cancer ; (12): 561-566, 2013.
Artigo em Inglês | WPRIM | ID: wpr-320596
ABSTRACT
Pediatric diffuse large B-cell lymphoma (DLBCL) is a highly aggressive disease with unique clinical characteristics. This study analyzed the germinal-center type B-cell (GCB) classification and clinical characteristics of Chinese pediatric DLBCL. A total of 76 patients with DLBCL newly diagnosed in Sun Yat-sen University Cancer Center between February 2000 and May 2011, with an age younger than 18 years, were included in the analysis. The male/female ratio was 3.471. The median age was 12 years (range, 2 to 18 years), and 47 (61.8%) patients were at least 10 years old. Of the 76 patients, 48 (63.2%) had stage III/IV disease, 9 (11.8%) had bone marrow involvement, 1 (1.3%) had central nervous system (CNS) involvement, and 5 (6.6%) had bone involvement. The GCB classification was assessed in 45 patients 26 (57.8%) were classified as GCB subtype, and 19 (42.2%) were classified as non-GCB subtype. The modified B-NHL-BFM-90/95 regimen was administered to 50 patients, and the 4-year event-free survival (EFS) rate was 85.8%. Among these 50 patients, 31 were assessed for the GCB classification 17 (54.8%) were classified as GCB subtype, with a 4-year EFS rate of 88.2%; 14 (45.2%) were classified as non-GCB subtype, with a 4-year EFS rate of 92.9%. Our data indicate that bone marrow involvement and stage III/IV disease are common in Chinese pediatric DLBCL patients, whereas the percentage of patients with the GCB subtype is similar to that of patients with the non-GCB subtype. The modified B-NHL-BFM-90/95 protocol is an active and effective treatment protocol for Chinese pediatric patients with DLBCL.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Asparaginase / Vincristina / Prednisona / Protocolos de Quimioterapia Combinada Antineoplásica / Daunorrubicina / Taxa de Sobrevida / Seguimentos / Linfoma Difuso de Grandes Células B / Intervalo Livre de Doença Tipo de estudo: Guia de Prática Clínica / Estudo observacional / Estudo prognóstico Limite: Adolescente / Criança / Criança, pré-escolar / Feminino / Humanos / Masculino Idioma: Inglês Revista: Chinese Journal of Cancer Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Asparaginase / Vincristina / Prednisona / Protocolos de Quimioterapia Combinada Antineoplásica / Daunorrubicina / Taxa de Sobrevida / Seguimentos / Linfoma Difuso de Grandes Células B / Intervalo Livre de Doença Tipo de estudo: Guia de Prática Clínica / Estudo observacional / Estudo prognóstico Limite: Adolescente / Criança / Criança, pré-escolar / Feminino / Humanos / Masculino Idioma: Inglês Revista: Chinese Journal of Cancer Ano de publicação: 2013 Tipo de documento: Artigo