Effects of early treatment on physical and intelligence development in children with congenital hypothyroidism / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 418-421, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-320631
ABSTRACT
<p><b>OBJECTIVE</b>To compare differences in the intelligence and physical developmental levels of children with congenital hypothyroidism (CH) who received initial treatment at different times.</p><p><b>METHODS</b>Forty-nine children with CH diagnosed by neonatal screening between September 2008 and September 2011 were enrolled in this study. According to the timing of initial treatment with thyroid hormone, they were classified into two groups <1 month and 1 to 3 months of life. At 6 months old, 1 year and 2 years old, their intelligence levels were evaluated by Gessell test. Their physical developmental levels were also measured. Their thyroid functions were examined with fluorescence immunoassay.</p><p><b>RESULTS</b>With treatment, there were no significant differences in thyroid hormones (FT3, FT4 and TSH) between the two groups (P>0.05) at 6 months old, 1 year and 2 years old. However, heights and weights in the <1 month treatment group were significantly higher than in the 1 to 3 months treatment group at all time points (P<0.05). At 6 months old, intelligence developmental levels in the <1 month treatment group were better than the 1 to 3 months treatment group (P<0.05) but significant differences were not noted at 1 and 2 years old (P>0.05).</p><p><b>CONCLUSIONS</b>The timing of initial treatment with thyroid hormone appears to be associated with the intelligence and physical development in children with CH. Treatment starting at less than 1 month of life contributes to improved physical and intelligence development compared with treatment starting at 1 to 3 months of life.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Psicologia
/
Tiroxina
/
Estatura
/
Peso Corporal
/
Desenvolvimento Infantil
/
Hipotireoidismo Congênito
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Inteligência
Limite:
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2012
Tipo de documento:
Artigo
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