Treatment of myocardial damage with creatine phosphate following neonatal asphyxia: a meta-analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 172-176, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-320693
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of creatine phosphate (CP) in the treatment of myocardial damage following neonatal asphyxia.</p><p><b>METHODS</b>Medical databases were searched for a systematic literature review and meta-analysis of randomized and quasi-randomized trials on the treatment of myocardial damage with CP following neonatal asphyxia. The data was analyzed using Review Manager 5.1.</p><p><b>RESULTS</b>Six trials involving 400 patients (CP treatment/control 202/198) were included in the survey. The meta-analysis indicated that CP treatment for 7 days decreased serum myocardial enzyme levels (CK, CK-MB, LDH, HBDH and cTnI levels). Both the total effective rate (RR 1.29; 95% CI 1.12, 1.48) and the significantly effective rate (RR 1.78; 95% CI 1.32, 2.41) in the CP treatment group were significantly higher than in the control group. CP treatment reduced the hospitalization period by 4.07 days compared with the control group (95% CI -5.25, -2.89).</p><p><b>CONCLUSIONS</b>CP treatment appears to be more effective than routine treatment alone for myocardial damage following neonatal asphyxia. It appears to be safe and it can both decrease serum myocardial enzyme levels and shorten the period of hospitalization. However, as the evidence obtained in this study is not robust due to the poor quality of current studies, further studies of high-quality, large-scale trails are needed.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fosfocreatina
/
Asfixia Neonatal
/
Cardiotônicos
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Miócitos Cardíacos
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Tempo de Internação
/
Cardiomiopatias
Tipo de estudo:
Ensaio Clínico Controlado
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
/
Recém-Nascido
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2012
Tipo de documento:
Artigo
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