Effect of the interaction between paranoxonase 1 and ATP-binding cassette transporter 1 gene polymorphism on serum lipid level / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 272-276, 2005.
Article
em En
| WPRIM
| ID: wpr-321108
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ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of interaction between paranoxonase 1 (PON1)gene polymorphism and ATP-binding cassette transporter 1 (ABCA1) genetic variation on serum lipid level.</p><p><b>METHODS</b>Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON1 A/B192 and ABCA1R219K genotype of 1019 subjects, including 680 patients with strokes and 339 healthy individuals as controls.</p><p><b>RESULTS</b>No significant association between A/B192 genotype and any of the lipid measurements was detected. The levels of HDL-C in the subjects with RR, RK and KK genotypes showed a significant upward tendency respectively (P < 0.05); the levels of their triglyceride (TG) tended downward respectively, but there were no significant differences between them. The relationship between R219K genotype and serum lipid level was modified by A/B192 genotype. The levels of HDL-C in the subjects with AA/RR genotype and BB/KK genotype [(1.41 +/- 0.40) mmol/L, (1.41 +/- 0.39) mmol/L] were significantly different from that in the subjects with BB/RR genotype [(1.28 +/- 0.36) mmol/L] (P < 0.05).</p><p><b>CONCLUSION</b>The result exhibited an interaction of PON1 A/B192 and ABCA1 R219K on serum lipid level.</p>
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Assunto principal:
Polimorfismo Genético
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Sangue
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Sequência de Bases
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Reação em Cadeia da Polimerase
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Análise de Sequência de DNA
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Transportadores de Cassetes de Ligação de ATP
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Arildialquilfosfatase
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Genética
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Genótipo
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Lipídeos
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2005
Tipo de documento:
Article