Screening for ZNF230 gene mutation and analysis of its correlation with azoospermia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 258-260, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-321112
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the possible association between ZNF230 gene and azoospermia.</p><p><b>METHODS</b>Screening for mutation of all 6 exons of ZNF230 gene was performed by denaturing high performance liquid chromatography(DHPLC) in 99 patients with azoospermia and in 115 healthy men as controls.</p><p><b>RESULTS</b>An A-->G transition at nucleotide 316 in exon 6 was identified. There were significant differences in the distribution profiles of both allele and genotype frequencies between patient group and control group (P < 0.01 and P < 0.05, respectively). In addition,there was a statistically significant difference in the serum follicle stimulating hormone (FSH) level between the patients with GG/GA genotype and those with AA genotype (P < 0.05).</p><p><b>CONCLUSION</b>ZNF230 gene may be associated with azoospermia, and the A316G mutation may be correlated with the serum FSH level.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Análise Mutacional de DNA
/
Sequência de Bases
/
Testes Genéticos
/
Reação em Cadeia da Polimerase
/
Cromatografia Líquida de Alta Pressão
/
Diagnóstico
/
Proteínas de Ligação a DNA
/
Azoospermia
/
Frequência do Gene
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2005
Tipo de documento:
Artigo
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