Relationship of APOE gene polymorphism with subclasses of serum high density lipoprotein in hyperlipidemia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 615-618, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-321182
ABSTRACT
<p><b>OBJECTIVE</b>To investigate apolipoprotein E(apoE) polymorphism and its relationship with serum lipids and apolipoprotein, serum high density lipoprotein (HDL) subclasses in patients with hyperlipidemia(HL).</p><p><b>METHODS</b>APOE genotype was assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The subclasses of serum HDL in 112 patients with hyperlipidemia and 73 healthy subjects were determined by two-dimensional gel electrophoresis in conjunction with immunodetection method.</p><p><b>RESULTS</b>APOE3/3 genotypes and allele epsilon3 frequency in HL group and control group were both the highest. In HL group, the genotype of APOE2 had higher serum APOE/CIII ratio and lower HDL3b levels, compared with the genotype of APOE3 (P<0.05). In control group, the genotype of apoE2 had higher serum triglycerides, APOE levels and APOE/CIII ratio, compared with the genotype of APOE3 and APOE4 (P<0.05).</p><p><b>CONCLUSION</b>Polymorphism of APOE gene may relate to the distribution of HDL particles.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apolipoproteínas E
/
Triglicerídeos
/
Sangue
/
Polimorfismo de Fragmento de Restrição
/
Reação em Cadeia da Polimerase
/
Colesterol
/
Classificação
/
Apolipoproteína E2
/
Apolipoproteína E3
/
Frequência do Gene
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2004
Tipo de documento:
Artigo
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