Goal-directed fluid management prevents gastrointestinal complications in abdominal surgery: a meta-analysis of randomized controlled trials / 中华胃肠外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To assess whether goal-directed fluid management can prevent gastrointestinal complications in major surgery.</p><p><b>METHODS</b>Electronic databases including Cochrane library(Issue 3,2010), Pubmed, EMbase, Highwire, CBM, and CNKI were searched. The date of search was between January 2000 and December 2010. Randomized controlled trials(RCTs) were indentified studying association of goal-directed therapy (GDT) with gastrointestinal complications. Study selection and meta-analysis were conducted according to the Cochrane Handbook for systematic reviews. Data were extracted from these trials by 3 reviewers independently and analyzed by RevMan 5.0 software.</p><p><b>RESULTS</b>Ten trials involving 775 patients were included. GDT significantly improved oxygen supply(WMD=82.95, 95% CI 17.43-148.46). GDT reduced postoperative hospital stay(WMD=-2.06, 95% CI -2.95 - -1.17) and decreased postoperative complication rate after major surgery(RR=0.39, 95% CI 0.29-0.52).</p><p><b>CONCLUSION</b>Goal-directed fluid management can stabilize cardiac output, augment oxygen supply, and therefore reduce postoperative complications.</p>