Studies on hydroxyapatite applicatied in coprecipitate of total salvianolic acids phospholipid complex / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 992-996, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-321380
ABSTRACT
The purpose of this research was to prepare total salvianolic acids-phytosome-HA coprecipitate to improve drug dissolution and its micromeritic properties. Firstly, the coprecipitate was prepared by solvent method and in vitro dissolution of tripterine was performed with the salvianolic acid B and danshensu as criteria. At the same time, the micromeritic properties was characterizated, the structure of samples was characterized by TEM, DSC, XRD and FTIR. Results showed that when the ratio of drug to HA was 12, it had a better dissolution, the accumulative drug-release percent in vitro at 60 min was over 90%. At the same time, it has good liquidity and low moisture absorption. Its micromeritic properties have improved. It is proved that the drug still existed amorphously by microstructure analysis. The preparation process is simple and feasible, it has practical value.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfolipídeos
/
Precipitação Química
/
Fatores de Tempo
/
Química
/
Química Farmacêutica
/
Durapatita
/
Alcenos
/
Polifenóis
/
Métodos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Artigo
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