Antimicrobial effects of erythromycin microspheres against Mycoplasma Pneumoniae in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1875-1877, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-321797
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the antimicrobial effects of erythromycin microspheres against Mycoplasma pneumoniae in rats.</p><p><b>METHODS</b>With erythromycin lactobionate as the positive control, erythromycin microspheres at 3 non-toxic doses (0.1, 0.5, and 1.2 g.kg(-1).d(-1)) were administered intragastrically for 6 consecutive days in Wistar rats with Mycoplasma pneumoniae infection. The general condition and lung index of the rats were observed and measured to assess the therapeutic effects of the treatments against Mycoplasma pneumoniae infection.</p><p><b>RESULTS</b>The erythromycin microspheres at 0.1, 0.5, 1.2 g.kg(-1).d(-1) significantly alleviated the symptoms of the rats infected with Mycoplasma pneumoniae and reduced the pulmonary index of the infected rats from 1.75 to 1.45, 1.38 and 1.25, respectively (P < 0.01). An obvious dosage-effect relationship was noted between the dose of erythromycin microsphere and the tissue pathologies due to the infection.</p><p><b>CONCLUSION</b>Erythromycin microspheres possess strong activity against Mycoplasma pneumoniae in rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pneumonia por Mycoplasma
/
Distribuição Aleatória
/
Eritromicina
/
Ratos Wistar
/
Tratamento Farmacológico
/
Microesferas
/
Mycoplasma pneumoniae
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2008
Tipo de documento:
Artigo
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