Effect of ablations by pulsed versus continuous high-intensity focused ultrasound on isolated perfused porcine liver / 南方医科大学学报
Journal of Southern Medical University
;
(12): 230-234, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-322075
ABSTRACT
<p><b>OBJECTIVE</b>To compare the effect of ablations with pulsed and continuous high-intensity focused ultrasound (HIFU) on the target area containing large blood vessels in isolated perfused porcine liver.</p><p><b>METHODS</b>An isolated perfused liver model was established by perfusing the isolated porcine liver with autologous blood through the portal vein and hepatic artery using an cardiopulmonary bypass machine. With B-mode ultrasound guidance, a blood vessel about 4 mm in diameter was selected, and pulsed and continuous HIFU ablation at the same dose was delivered along the blood vessel at 3 mm to the vascular wall. After the ablation, the damages of the blood vessels as the acoustic channel and the target area were inspected, and the tissues at the interface of target volume and blood vessels were sampled for pathological examination.</p><p><b>RESULTS</b>Neither pulsed nor continuous HIFU caused noticeable injuries of the acoustic channel vessels, but the volume of necrotic tissues in the target area differed significantly between the two groups (P<0.05). HE staining and vessel staining did not show any injuries of the blood vessels in the pathway of ultrasound ablation in neither of the groups (P>0.05).</p><p><b>CONCLUSION</b>When the target area contains large blood vessels in the pathway of ultrasound ablation, pulsed HIFU can have better therapeutic efficiency to effectively induce tissue damages without affecting the blood vessels.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Suínos
/
Modelos Animais de Doenças
/
Circulação Extracorpórea
/
Ablação por Ultrassom Focalizado de Alta Intensidade
/
Artéria Hepática
/
Veias Hepáticas
/
Fígado
/
Métodos
Tipo de estudo:
Guia de Prática Clínica
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS