Expression of glypican-3 in lung squamous cell carcinoma and adenocarcinoma and its relation with prognosis / 南方医科大学学报
Journal of Southern Medical University
; (12): 212-215, 2013.
Article
em Zh
| WPRIM
| ID: wpr-322079
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the different expressions of glypican-3 in lung squamous cell carcinoma and adenocarcinoma and explore the association of glypican-3 with the prognosis of the patients.</p><p><b>METHODS</b>Glypican-3 expression was detected immunohistochemically in the tumor tissues and adjacent tissues from 48 cases of lung squamous cell carcinoma and adenocarcinoma. Kaplan-Meier method and log-rank test were used for survival analysis of the patients.</p><p><b>RESULTS</b>Glypican-3 expression was detected in the tumor tissues in 29.2% (14/48) of the cases, but not in the adjacent tissues. Of the 22 patients with lung squamous cell carcinoma, 12 (54.5%) showed positive glypican-3 expression in the tumor tissue, a rate significantly higher than that in patients with lung adenocarcinoma [7.7% (2/26), P<0.01]. In all the glypican-3-positive cases, the tumor tissues showed stronger glypican-3 expression in cases with lymph node metastasis or poor tumor differentiation. Kaplan-Meier survival analysis did not indicate a significant correlation of glypican-3 expression with the prognosis of the lung cancer patients.</p><p><b>CONCLUSION</b>Patients with lung squamous cell carcinoma have higher glypican-3 expressions in the tumor tissues than those with lung adenocarcinoma, suggesting the value of glypican-3 protein as a potential marker to detect lung squamous cell carcinoma.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Prognóstico
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Carcinoma de Células Escamosas
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Adenocarcinoma
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Regulação Neoplásica da Expressão Gênica
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Inclusão em Parafina
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Glipicanas
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Estimativa de Kaplan-Meier
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Neoplasias Pulmonares
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Metabolismo
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2013
Tipo de documento:
Article