Your browser doesn't support javascript.
loading
Expression of glypican-3 in lung squamous cell carcinoma and adenocarcinoma and its relation with prognosis / 南方医科大学学报
Journal of Southern Medical University ; (12): 212-215, 2013.
Artigo em Chinês | WPRIM | ID: wpr-322079
ABSTRACT
<p><b>OBJECTIVE</b>To study the different expressions of glypican-3 in lung squamous cell carcinoma and adenocarcinoma and explore the association of glypican-3 with the prognosis of the patients.</p><p><b>METHODS</b>Glypican-3 expression was detected immunohistochemically in the tumor tissues and adjacent tissues from 48 cases of lung squamous cell carcinoma and adenocarcinoma. Kaplan-Meier method and log-rank test were used for survival analysis of the patients.</p><p><b>RESULTS</b>Glypican-3 expression was detected in the tumor tissues in 29.2% (14/48) of the cases, but not in the adjacent tissues. Of the 22 patients with lung squamous cell carcinoma, 12 (54.5%) showed positive glypican-3 expression in the tumor tissue, a rate significantly higher than that in patients with lung adenocarcinoma [7.7% (2/26), P<0.01]. In all the glypican-3-positive cases, the tumor tissues showed stronger glypican-3 expression in cases with lymph node metastasis or poor tumor differentiation. Kaplan-Meier survival analysis did not indicate a significant correlation of glypican-3 expression with the prognosis of the lung cancer patients.</p><p><b>CONCLUSION</b>Patients with lung squamous cell carcinoma have higher glypican-3 expressions in the tumor tissues than those with lung adenocarcinoma, suggesting the value of glypican-3 protein as a potential marker to detect lung squamous cell carcinoma.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Carcinoma de Células Escamosas / Adenocarcinoma / Regulação Neoplásica da Expressão Gênica / Inclusão em Parafina / Glipicanas / Estimativa de Kaplan-Meier / Neoplasias Pulmonares / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2013 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Prognóstico / Carcinoma de Células Escamosas / Adenocarcinoma / Regulação Neoplásica da Expressão Gênica / Inclusão em Parafina / Glipicanas / Estimativa de Kaplan-Meier / Neoplasias Pulmonares / Metabolismo Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2013 Tipo de documento: Artigo