Pharmaceutical screening of the effective fraction from Smilax for treatment of chronic pelvic inflammatory disease / 南方医科大学学报
Journal of Southern Medical University
; (12): 145-149, 2013.
Article
em Zh
| WPRIM
| ID: wpr-322094
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the effective fraction of Smilax for treatment of chronic pelvic inflammatory disease (CPID) by pharmacodynamic screening as the basis for further development of sarsaparilla preparations.</p><p><b>METHODS</b>The chemical fractions of Smilax were administered intragastrically in rat models of CPID induced by injecting phenol mucilage into the uterus to observe the therapeutic effects. The anti-inflammatory effects of different extract fractions from Smilax were tested in mice with xylene-induced ear edema and in rats with cotton-ball-induced granuloma.</p><p><b>RESULTS</b>High-dose ethyl acetate extract of Smilax could obviously inhibit uterus inflammation in rats with CPID, showing also strong anti-inflammatory effects against ear edema in mice and granuloma in rats (P<0.01). The moderate dose of ethyl acetate extract also obviously ameliorated the inflammation. Both the ethyl acetate extract fraction and the total extract fraction of Smilax showed anti-inflammatory effects, while the former produced strong effects while the latter has only weak actions.</p><p><b>CONCLUSION</b>The ethyl acetate extract fraction of Smilax is the effective fraction to produce anti-inflammatory and anti-CPID effects.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Medicamentos de Ervas Chinesas
/
Doença Inflamatória Pélvica
/
Ratos Sprague-Dawley
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Smilax
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Usos Terapêuticos
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Avaliação Pré-Clínica de Medicamentos
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Tratamento Farmacológico
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Camundongos Endogâmicos
/
Anti-Inflamatórios
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2013
Tipo de documento:
Article