Study on a 10-year protective effects of vaccination against hemorrhagic fever with renal syndrome / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1190-1193, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-322827
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the epidemiological and serological efficacy after 10 years of vaccination against hemorrhagic fever with renal syndrome (HFRS) vaccines in Zhejiang province.</p><p><b>METHODS</b>One county was randomly chosen as the research unit with all the healthy people between 16 and 60 years old were equally divided into study and control groups. The study group was vaccinated. Immunofluorescent antibody assay was used to test specific IgG antibody and Mcro-CPE method was used to test the titer of neutralizing antibody.</p><p><b>RESULTS</b>Two weeks after the full-course immunization, the seroconversion rate became 100% (67/67, with 95% CI as 96.3%-100%) by immunofluorescent antibody test (IgG) and 44.4% (8/18 with 95% CI as 22.0%-69.0%) by neutralization test with GMT titers as 72.1 and 4.6 respectively. Booster immunization was provided one year later. Time span as two weeks prior to, one year, one and half years, two years, three years and five years after booster immunization, the rates of seroconversion on immunofluorescent antibody using IFAT method, were 28.6%, 83.3%, 75.0%, 53.1%, 22.6%, 10.0% and 55.0% respectively, and rates of seroconversion of neutralizing antibody by Mcro-CPE method were 14.8%, 55.6%, 35.0%, 31.3%, 26.0%, 10.0% and 50.0% respectively. Nine years after the reinforcement, the rates of seroconversion of immunofluorescent antibody by IFAT method was only 7.1%. The vaccinated group had no patient seen but the control group appeared 34 patients including 3 deaths. According to the ten-year observation, the vaccine seemed effective with the protection rate in population reached 100%.</p><p><b>CONCLUSION</b>HFRS vaccine was effective on epidemiological, social and economical efficacy.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vacinas Virais
/
Epidemiologia
/
Imunização Secundária
/
Vacinação
/
Usos Terapêuticos
/
Alergia e Imunologia
/
Febre Hemorrágica com Síndrome Renal
/
Métodos
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2007
Tipo de documento:
Artigo
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