Research progress of liver X receptor agonists / 药学学报
Acta Pharmaceutica Sinica
;
(12): 427-433, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-323024
ABSTRACT
Liver X receptor (LXR), a member of the superfamily of nuclear receptors, plays an important role in the activation of transcription factors involved in cholesterol metabolism, glucose homeostasis inflammation and lipogenesis. It is shown that LXR agnoists have the potentiality to be used as drugs for the prevention and treatment of atherosclerosis, which is its best investigated therapeutic indication. There are many compounds being studied in preclinical evaluation and biological assay. This paper will review briefly the LXR agonists in recent years.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fisiologia
/
Quinolinas
/
Benzimidazóis
/
Química
/
Colesterol
/
Transportadores de Cassetes de Ligação de ATP
/
Tratamento Farmacológico
/
Aterosclerose
/
Proteína de Ligação a Elemento Regulador de Esterol 1
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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