ESI fragmentation studies of six unusual nucleotide sugars / 药学学报
Acta Pharmaceutica Sinica
;
(12): 374-379, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-323033
ABSTRACT
Unusual dTDP-sugars are key intermediate in many pathogenic bacteria. In this study, negative-ion electrospray tandem mass spectrometry (ESI-MS-MS) with collision-induced dissociation (CID) was used to study the fragmentation characteristics of six unusual nucleotide diphosphate sugars. The results indicated the major fragment of the six unusual nucleoside sugars observed in the ESI-MS-MS spectra resulted from cleavage of diphosphate moiety and their characteristic fragment ions at m/z 401, 383, and 321, correspond to [TDP-H] together with fragment ions resulting from the loss of water and phosphate moiety, respectively. Furthermore, 4-position substituted change of unusual sugar rings affected the stability of two important characteristic fragment ions of [glycosyl-1"-PO3](-) and [glycosyl-1"-P2O6](-).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estrutura Molecular
/
Química
/
Espectrometria de Massas por Ionização por Electrospray
/
Espectrometria de Massas em Tandem
/
Métodos
/
Açúcares de Nucleosídeo Difosfato
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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