Coumarins of Anemone raddeana Regel and their biological activity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 206-209, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-323057
ABSTRACT
To study the coumarins of Anemone raddeana Regel, the compounds were separated by silica gel column chromatography and HPLC. Their structures were identified by their physicochemical property and spectral analysis. Two new compounds were isolated and identified as 4, 7-dimethoxyl-5-methyl-6-hydroxy coumarin (1) and 4, 7-dimethoxyl-5-formyl-6-hydroxycoumarin (2). The bioassays indicated that compounds 1 and 2 could significantly inhibit the proliferation of cancer cell, and showed the agonist effect on the transactivity of retinoic acid receptor-alpha (RARalpha). In addition, the two compounds had inhibitory effect against human leukocyte elastase (HLE).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Estrutura Molecular
/
Ativação Transcricional
/
Química
/
Receptores do Ácido Retinoico
/
Elastase de Leucócito
/
Concentração Inibidora 50
/
Cumarínicos
/
Rizoma
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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