Design, synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 194-199, 2012.
Article
em Zh
| WPRIM
| ID: wpr-323059
Biblioteca responsável:
WPRO
ABSTRACT
To explore new agents of gamma-aminobutyric acid (GABA) derivatives with more potent antiepileptic activity, a series of 4-(2-acetoxybenzoylamino) butyramide derivatives were designed and synthesized. All of the novel compounds (5a-51) were synthesized from GABA as starting material, and their structures were confirmed with IR, 1H NMR, EI-MS and elemental analysis. Preliminary pharmacological test in vitro showed that all target compounds displayed strong antiepileptic activities and were worth for further study. The structure-activity relationship of 4-(2-acetoxybenzoylamino) butyramide derivatives was also discussed preliminarily.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Relação Estrutura-Atividade
/
Estrutura Molecular
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Distribuição Aleatória
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4-Aminopiridina
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Química
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Usos Terapêuticos
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Tratamento Farmacológico
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Epilepsia
/
Amidas
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Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Article