Synthesis and anti-tumor activity of paeonol and its derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 72-76, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-323078
ABSTRACT
A series of paeonol derivatives have been synthesized by simple acylation and etherification of the paeonol. Anti-tumor activities of the synthesized compounds were evaluated against HeLa and MCF-7 cells lines in vitro by the standard MTT assay. It was found that the derivatives were more active against HeLa than MCF-7. The results also indicated that 4-methoxy group is the synergistic group of paeonol's anti-tumor activity and ketone carbonyl side chain is essential functional group of paeonol's anti-tumor activity. Compound 2d had stronger antiproliferative activities than paeonol against HeLa and MCF-7 cell lines with IC50 values of 2.67 and 4.74 micromol x L(-1) respectively. The results showed that paeonol derivatives were worth to be intensively studied further.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acetofenonas
/
Farmacologia
/
Relação Estrutura-Atividade
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Células HeLa
/
Química
/
Concentração Inibidora 50
/
Proliferação de Células
/
Células MCF-7
/
Antineoplásicos Fitogênicos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo
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