Study on semi-synthetic transforming technology for the natural product of isocorydione / 药学学报
Acta Pharmaceutica Sinica
; (12): 1471-1475, 2011.
Article
em Zh
| WPRIM
| ID: wpr-323099
Biblioteca responsável:
WPRO
ABSTRACT
Transforming technology for semi-synthesized isocorydione from the natural product ofisocorydine was studied. The factors affecting on the reaction yield were investigated. UV spectrophotometry was used to indicate the semi-synthesized yield of isocorydione. The optimum reaction conditions were determined as following: reacting for 12 h in the solution of sodium dihydrogen phosphate at pH 10, the temperature was 25 degrees C and the ratio of isocorydine to Fremy's radical was 1 : 2. Under the optimum conditions, the yield could reach up to 50.0%. The molecular structure of isocorydione was elucidated by X-ray single-crystal diffraction analysis for the first time.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oxirredução
/
Aporfinas
/
Plantas Medicinais
/
Espectrofotometria Ultravioleta
/
Temperatura
/
Difração de Raios X
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Estrutura Molecular
/
Química
/
Cristalografia por Raios X
/
Papaveraceae
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Article