Compound erythromycin sustained release preparation and its in vitro release / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1385-1389, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-323112
ABSTRACT
Using the weight-average molecular weight 50 000 polylactic acid (PLA) as a carrier, and a certain proportion of erythromycin (EM) and prednisone acetate (PNA) to mixed prepare the compound erythromycin sustained release preparation (sustained-release tablets). Using ultraviolet spectrophotometry and high performance liquid chromatography (HPLC) to detect separately the release amount of EM and PNA in vitro medium. The sustained-release tablets release for about 21 days, the average content of EM is 99.7 mg/table, RSD = 0.82%; and the average content of PNA is 10.03 mg/table, RSD = 0.93%. Within 21 days, the cumulative releases of EM and PNA are 86.1% and 78.3%, respectively. The drug release is steady and slow after 5 days, the burst release phenomenon in early stage is more significant. The results showed that the sustained-release tablet preparation method is feasible, the release performance is good and the clinical efficacy is significant.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Poliésteres
/
Polímeros
/
Sinusite
/
Espectrofotometria Ultravioleta
/
Comprimidos
/
Prednisona
/
Portadores de Fármacos
/
Química
/
Eritromicina
/
Cromatografia Líquida de Alta Pressão
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo
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