Study on determination of relationship between releasing rate in vitro and absorption rate in vivo of sodium diclofenac 100mg tablets LA

ABSTRACT

The in vitro correlation of sustained release sodium diclofenac 100mg capsule was characterized. Correlation at level A was established between the rate of in vitro release and that of in vivo absorption. Correlation coefficient was found at 0.9705. This correlation coefficient was found at dissolution test used in this research could be applied for quality control of the capsule. The results of the research also showed that the absorption in vivo was suitable for once-a-day dosage form.