T cell receptor constant alpha chain gene +1592C/T polymorphism may not be associated with IgA nephropathy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2298-2300, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-323677
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between T cell receptor constant alpha chain (TCRCα) gene +1592C/T polymorphism and IgA nephropathy.</p><p><b>METHODS</b>TCRCα +1592C/T genotypes were identified by PCR-RFLP and direct sequencing in 244 Chinese Han patients with IgA nephropathy, who were classified according to their genotype into CC (188 cases), CT (54 cases) and TT (2 cases) groups. The clinical and pathological data of the patients were analyzed in relation to the TCRCα +1592C/T genotypes.</p><p><b>RESULTS</b>No significant differences in the clinical and biochemical indices were found in these patients with different TCRCα gene +1592C/T genotypes. TCRCα +1592C/T polymorphism was not found to contribute to severity or manifestations of renal pathology.</p><p><b>CONCLUSIONS</b>TCRCα+1592C/T polymorphism may not be associated with the susceptibility to IgA nephropathy in the Chinese Han population.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Cromossomos Humanos Par 14
/
Polimorfismo de Fragmento de Restrição
/
Receptores de Antígenos de Linfócitos T alfa-beta
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Frequência do Gene
/
Genética
/
Genótipo
/
Glomerulonefrite por IGA
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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