TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease / 南方医科大学学报
Journal of Southern Medical University
; (12): 2246-2248, 2010.
Article
em Zh
| WPRIM
| ID: wpr-323692
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between single nucleotide polymorphisms of thioredoxin reductase-2 (TrxR2) gene and the susceptibility to Kashin-Beck disease (KBD).</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the genotype frequencies of rs5748469 in TrxR2 gene in 84 KBD patients and 109 healthy control subjects.</p><p><b>RESULTS</b>The genotype frequencies of A/A, A/C, and C/C in the KBD patients were 83.33%, 15.48% and 1.19%, as compared with the frequencies of 74.31%, 25.69%, and 0.00% in the healthy control, respectively, showing no significant difference in the single nucleotide polymorphisms of TrxR2 gene between the two groups (P=0.13).</p><p><b>CONCLUSION</b>No obvious correlation can be found between rs5748469 polymorphisms in TrxR2 gene and the susceptibility to KBD.</p>
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Índice:
WPRIM
Assunto principal:
Polimorfismo de Fragmento de Restrição
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Alelos
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Tiorredoxina Redutase 2
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Doença de Kashin-Bek
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Genética
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Genótipo
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Article