Protective Effect of Etomidate on Kainic Acid-induced Neurotoxicity in Rat Hippocampus / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 794-801, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-32416
ABSTRACT
BACKGROUND:
The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by using the immunoreactivity of heat shock protein-70 (HSP-70) and the acid-fuchsin stain.METHODS:
Administration of etomidate (20 mg/kg, I.P.) was performed in sequence; first being just one hour after a KA (10 mg/kg, I.P.) injection, then three more times at one hour intervals. Neuronal damages in the hippocampus were evaluated by using the acid-fuchsin stain to detect cell death and HSP-70 induction as an index of cell injury at 24 h after the administration of KA.RESULTS:
HSP-70 induction and acid fuchsin positive neurons were increased in the CA1 and CA3 regions of the hippocampus after a KA injection but significantly decreased by an injection of etomidate (P < 0.01).CONCLUSIONS:
These results suggest that the etomidate has a potential effect on the protection of neurons against KA-induced neurotoxicity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Corantes de Rosanilina
/
Choque
/
Morte Celular
/
Fármacos Neuroprotetores
/
Etomidato
/
Temperatura Alta
/
Hipocampo
/
Ácido Caínico
/
Neurônios
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2001
Tipo de documento:
Artigo
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